ROYBAL PILOT PROGRAM

Funding Announcement

The Brigham and Women's Hospital (BWH) Roybal Center for Therapeutic Optimization Using Behavioral Science (funded through NIA RFA-AG-19-006) seeks to develop and test principle-driven, potent, practical, scalable, and sustainable behavioral interventions to enhance the appropriate prescribing of and adherence to evidence-based medications.

We are pleased to issue a call for pilot proposals for randomized studies that seek to test behavioral interventions aimed at improving evidence-based medication use. For the upcoming year, the Brigham and Women’s Hospital Roybal Center will support 2-3 projects with a maximum annual direct cost of $165,000. Most projects will be funded for a 12-month period starting June 1, 2021 although multi-year studies will also be considered.

Successful proposals will exhibit the following 3 key features: 

  1. a multi-disciplinary approach integrating collaborators with expertise in medication use, theory-based behavioral science, implementation research, and/or data science

  2. the testing of principle-driven interventions in real-world settings 

  3. the use of novel analytic methods and technological approaches to gain a deeper understanding of behavior and to facilitate the creation of interventions that are both personalized but applicable to population health improvement

Eligibility
Per the parent Roybal RFA, eligible investigators for pilot studies include, but are not limited to, junior, under-represented and established investigators from academic, non-profit or corporate institutions. Junior investigators and applicants who have not previously received funding through the BWH Roybal Center for Therapeutic Optimization Using Behavioral Science are encouraged to apply but partnership with Center-affiliated faculty and individuals who have experience successfully conducting pragmatic clinical trials of behavioral interventions is strongly recommended.

 

If prospective applicants would like assistance in assembling an appropriate investigative team, we would be pleased to provide consultative assistance and can be contacted at c4hds@bwh.harvard.edu.

Evaluation criteria

Applications will be evaluated by the Center’s Executive Committee using the following criteria: 

  1. the strength of the principle-driven intervention being evaluated

  2. the potential of the project to promote healthy aging

  3. novelty/innovation

  4. feasibility

  5. investigative team quality and diversity 

  6. the potential to lead to follow-on funding such as an R01.

 

Examples of successfully funded projects can be found here.

 

Letter of Intent and application process

Applicants should submit a 1-2 page letter of intent with the following information:

  • Descriptive title of proposed activity

  • Brief description of proposed pilot study

  • Name(s), address(es), and telephone number(s) of the pilot PI(s)

  • Names of other key personnel

  • Participating institution(s)

  • Estimated budget (total direct and indirect)

 

The LOI should be addressed to Niteesh Choudhry, MD, PhD, Center Director, and submitted via email to c4hds@bwh.harvard.edu by December 31, 2020 at 5p ET.

Those LOIs highly ranked by the Executive Committee will be invited to submit a full application by February 1, 2021 with the following components:

  • Research Strategy: In this document, please include your specific aims and explain the principle-driven intervention or basic behavioral science concept that you are interested in evaluating. Your application should emphasize the underlying theory and its potential to optimize medication use and to promote healthy aging and provide sufficient methodological detail to allow for accurate assessment of the validity and feasibility of the proposed approach. The research proposal should be no longer than three (3) single-spaced pages with one-inch margins and should use Arial 11-point font.

  • NIH Biosketch: An NIH format biographical sketch must be submitted for the PI(s) and all Co-Is.

  • Budget and budget justification: Please use the PHS 398 template budget page and provide detailed expenses.  Please also provide a short justification for all personnel, supplies, and equipment that will be expensed to this project.

 

Successful applications will be notified by March 1, 2021. Chosen pilot projects will require additional documentation such as a Data Safety Monitoring Plan and Human Subjects for submission to NIA for final approval by April 1, 2021. 

 

Awarded pilot projects will begin June 1, 2021. 

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