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The cost of prescription drugs is a central reason for nonadherence, even for patients with drug insurance. The Post-Myocardial Infarction Free Rx Event and Economic Evaluation (MI FREEE) trial was a large, national randomized study (n=5,855) conducted in partnership with Aetna that aimed to evaluate the effect of providing full prescription drug coverage (i.e., no copays, coinsurance, or deductibles) for evidence-based medications prescribed to patients who had recently had a myocardial infarction. Full coverage improved adherence, reduced rates of major vascular events, reduced patient out-of-pocket spending and led to non-significant reductions in total health spending as well as the composite outcome of major vascular events and revascularization. NCT00566774

Principal Investigator: Niteesh Choudhry, MD, PhD

Eliminating medication copayments reduces disparities in cardiovascular care.

Choudhry NK, Byvok K, Shrank WH, Toscano M, Rawlins W, Reisman L, Brennan T, Franklin JM.

Health Aff

2014 May

Untangling the relationship between medication adherence and post–myocardial infarction outcomes.

Choudhry NK, Glynn RJ, Avorn J, Lee JL, Brennan TA, Reisman L, Toscano M, Levin R, Matlin OS, Antman EM, Shrank WH.

Am Heart J

2014 January

Full prescription coverage versus usual prescription coverage after coronary artery bypass graft surgery: analysis from the post-myocardial infarction free Rx event and economic evaluation (FREEE) randomized trial.

Kulik A, Desai NR, Shrank WH, Antman EM, Glynn RJ, Levin R, Reisman L, Brennan T, Choudhry NK.


2013 September 10

Full Coverage for Preventive Medications after Myocardial Infarction

Choudhry NK, Avorn J, Glynn RJ, Antman EM, Schneeweiss S, Toscano M, Reisman L, Fernandes J, Spettell C, Lee JL, Levin R, Brennan T, Shrank WH

N Engl J Med

2011 December 1

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