The cost of prescription drugs is a central reason for nonadherence, even for patients with drug insurance. The Post-Myocardial Infarction Free Rx Event and Economic Evaluation (MI FREEE) trial was a large, national randomized study (n=5,855) conducted in partnership with Aetna that aimed to evaluate the effect of providing full prescription drug coverage (i.e., no copays, coinsurance, or deductibles) for evidence-based medications prescribed to patients who had recently had a myocardial infarction. Full coverage improved adherence, reduced rates of major vascular events, reduced patient out-of-pocket spending and led to non-significant reductions in total health spending as well as the composite outcome of major vascular events and revascularization.

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