Publications

2023

Medication de-escalation opportunities among frail older adults with strictly-controlled cardiometabolic disease

Chaitoff A, Haff N, Lauffenburger JC, Choudhry NK

J Am Geriatr Soc 2023 Apr 4

Clinicians' and Patients' Perspectives on Hypertension Care in a Racially and Ethnically Diverse Population in Primary Care

Lauffenburger JC, Barlev RA, Khatib R, Glowacki N, Siddiqi A, Everett ME, Albert MA, Keller PA, Samal L, Hanken K, Sears ES, Haff N, Choudhry NK

JAMA Netw Open 2023 Feb 28

Disagreement between pharmacy claims and direct interview to identify patients with non-adherence to chronic cardiometabolic medications

Haff N, Choudhry NK, Isaac T, Bhatkhande G, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD, Lauffenburger JC

Am Heart J 2023 Feb

Deficits and Disparities in Early Uptake of Glucagon-Like Peptide 1 Receptor Agonists and SGLT2i Among Medicare-Insured Adults Following a New Diagnosis of Cardiovascular Disease or Heart Failure

Cromer SJ, Lauffenburger JC, Levin R, Patorno E

Diabetes Care 2023 Jan 1

Reducing ethnic and racial disparities by improving undertreatment, control, and engagement in blood pressure management with health information technology (REDUCE-BP) hybrid effectiveness-implementation pragmatic trial: Rationale and design

Lauffenburger JC, Khatib R, Siddiqi A, Albert MA, Keller PA, Samal L, Glowacki N, Everett ME, Hanken K, Lee SG, Bhatkhande G, Haff N, Sears ES, Choudhry NK

Am Heart J 2023 Jan

2022

Effect of a Biopsychosocial Intervention or Postural Therapy on Disability and Health Care Spending Among Patients With Acute and Subacute Spine Pain: The SPINE CARE Randomized Clinical Trial

Choudhry NK, Fifer S, Fontanet CP, Archer KR, Sears E, Bhatkhande G, Haff N, Ghazinouri R, Coronado RA, Schneider BJ, Butterworth SW, Deogun H, Cooper A, Hsu E, Block S, Davidson CA, Shackelford CE, Goyal P, Milstein A, SPINE CARE Investigators, Crum K, Scott J, Marton K, Silva FM, Obeidalla S, Robinette PE, Lorenzana-DeWitt M, Bair CA, Sadun HJ, Goldfield N, Hogewood LM, Sterling EK, Pickney C, Koltun-Baker EJ, Swehla A, Ravikumar V, Malhotra S, Finney ST, Holliday L, Moolman KC, Coleman-Dockery S, Patel IB, Angel FB, Green JK, Mitchell K, McBean MR, Ghaffar M, Ermini SR, Carr AL, MacDonald J

JAMA 2022 Dec 20

Prescribing decision making by medical residents on night shifts: A qualitative study

Lauffenburger JC, Coll MD, Kim E, Robertson T, Oran R, Haff N, Hanken K, Avorn J, Choudhry NK

Med Educ 2022 Oct

Using data-driven approaches to classify and predict healthcare spending in patients with gout using urate-lowering therapy

Lauffenburger JC, Lu Z, Mahesri M, Kim E, Tong A, Kim SC.

Arthritis Care Res (Hoboken) 2022 Aug 30

Designing and conducting adaptive trials to evaluate interventions in health services and implementation research: practical considerations

Lauffenburger JC, Choudhry NK, Russo M, Glynn RJ, Ventz S, Trippa L.

BMI Med. 2022 Jul 1

Frequency of Quarterly Self-reported Health-Related Social Needs Among Older Adults, 2020

Haff N, Choudhry NK, Bhatkhande G, Li Y, Drzayich Antol D, Renda A, Lauffenburger JC.

JAMA Netw Open. 2022 Jun 30

Factors Associated with Lower Preoperative Quality of Life in Patients with Chronic Limb Threatening Ischemia in the BEST-CLI Trial

Powell RJ, Choudhry NK, Conte M, Cziraky M, Giles K, Hamza T, Menard M, Rosenfeld K, Rowe V, Siracuse J, Strong M, Van Over M, Villarreal M, White C, Farber A

J Vasc Surg. 2022 Jun 14

Leveraging Social Networks for the Assessment and Management of Neurological Patients

Dhand A, Podury A, Choudhry N, Narayanan S, Shin M, Mehl MR

Semin Neurol. 2022 Apr

Overcoming decisional gaps in high-risk prescribing by junior physicians using simulation-based training: Protocol for a randomized controlled trial

Lauffenburger JC, DiFrancesco MF, Barlev RA, Robertson T, Kim E, Coll MD, Haff N, Fontanet CP, Hanken K, Oran R, Avorn J, Choudhry NK

JMIR Res Protoc. 2022 Apr

A novel modality for real-time measurement of provider happiness

Carlile N, Tantillo S, Brown M, Bates DW, Choudhry NK

JAMIA Open. 2022 Feb 24

circoutcomes.2021.14.issue-12.largecover.jpg

Finishing Touches: Enhancing Scientific Communication Through Circulation: Cardiovascular Quality and Outcomes' Technical Review

Lauffenburger JC, Ho MP, Nallamothu BK

Circ Cardiovasc Qual Outcomes. 2021 Dec 21

2021

Three Sides to the Story: Adherence Trajectories During the First Year of Sodium-Glucose Cotransporter 2 Inhibitor Therapy Among Medicare Beneficiaries

Hawley CE, Lauffenburger JC, Paik JM, Wexler DJ, Kim SC, Patorno E

Diabetes Care. 2022 Jan 17

REinforcement learning to improve non-adherence for diabetes treatments by Optimising Response and Customising Engagement (REINFORCE): study protocol of a pragmatic randomised trial
Lauffenburger LC, Yum-Tov E, Keller PA, McDonnell ME, Bessette LG, Fontanet CP, Sears ES, Kim E, Hanken K, Buckley JJ, Barlev RA, Haff N, Choudhry NK

BMJ Open 2021 Dec 3

Randomised controlled trial targeting habit formation to improve medication adherence to daily oral medications in patients with gout
Fontanet CP, Choudhry NK, Wood W, Robertson T, Haff N, Oran R, Sears ES, Kim E, Hanken K, Barlev RA, Lauffenburger JC, Feldman CH

BMJ Open 2021 Nov 24

Exploring patient experiences coping with using multiple medications: a qualitative interview study
Lauffenburger JC, Haff N, McDonnell ME, Solomon DH, Antman EM, Glynn RJ, Choudhry NK

BMJ Open 2021 Nov 22

Prevalence, predictors, and outcomes of both true- and pseudo-resistant hypertension in the action to control cardiovascular risk in diabetes trial: a cohort study
Chiu N, Lauffenburger LC, Franklin JM, Choudhry NK

Hypertens Res 2021 Nov

Design of the Spine Pain Intervention to Enhance Care Quality And Reduce Expenditure Trial (SPINE CARE) study: Methods and lessons from a multi-site pragmatic cluster randomized controlled trial
Choudhry NK, Fontanet CP, Ghazinouri R, Fifer S, Archer KR, Haff N, Butterworth SW, Deogun H, Block S, Cooper A, Sears E, Goyal P, Coronado RA, Schneider BJ, Milstein A

Contemp Clin Trials 2021 Oct 22

Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association
Choudhry NK, Kronish IM, Congpatanasin W, Ferdinand KC, Pavlik VN, Egan BM, Schoenthaler A, Houston Miller N, Hyman DJ; American Heart Association Council on Hypertension; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology

Hypertension 2021 Oct 7

Comparison of measures of medication adherence from pharmacy dispensing and insurer claims data
Fontanet CP, Choudhry NK, Isaac T, Sequist TD, Gopalakrishnan C, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Lauffenburger JC

Health Serv Res 2021 Aug 13

Helping Patients Manage Their Own Blood Pressures: A Strategy to Address Hypertesnion Control in the United States
Haff N, Choudhry NK

Circ Cardiovasc Qual Outcomes 2021 Aug

Association Between Cost-Saving Prescription Policy Changes and Adherence to Chronic Disease Medications: an Observational Study
Haff N, Sequist TD, Gibson TB, Benevent R, Sears SE, Chaguturu S, Lauffenburger JC

J Gen Intern Med 2021 Jul 30

Impact of implementing electronic prior authorization on medication filling in an electronic health record system in a large healthcare system
Lauffenburger LC, Stults CD, Mudiganti S, Yan X, Dean-Gilley LM, He M, Tong A, Fischer MA

J Am Med Inform Assoc 2021 Jul 19

Association Between Primary Care Payment Model and Telemedicine Use for Medicare Advantage Enrollees During the COVID-19 Pandemic

Powers BW, Drzayich Antol D, Zhao Y, Haugh GS, Roman O, Shrank WH, Choudhry NK.

JAMA Health Forum 2021 Jul

JOURNAL OF MEDICAL INTERNET RESEARCH.jpg

Preferences for mHealth Technology and Text Messaging Communication in Patients With Type 2 Diabetes: Qualitative Interview Study

Lauffenburger JC, Barlev RA, Sears ES, Keller PA, McDonnel ME, Yom-Tov E, Fontanet CP, Hanken K, Haff N, Choudhry NK

J Med Internet Res 2021 Jun

Race/Ethnic Differences in Atherosclerotic Cardiovascular Disease Risk Factors Among Patients with Hypertension: Analysis from 143 primary care clinics

Khatib R, Glowacki N, Lauffenburger J, and Siddiqi A

Am J Hypertens 2021 Apr

Utilization and Spending on Potentially Inappropriate Medications by US Older Adults with Multiple Chronic Conditions using Multiple Medications

Jungo KT, Streit S, and Lauffenburger JC

Arch Gerontol Geriatr 2021 Mar-Apr

Virtual Optimization of Guideline-Directed Medical Therapy in Hospitalized Patients with Heart Failure with Reduced Ejection Fraction: the IMPLEMENT-HF Pilot Study

Bhatt AS, Varshney AS, Nekoui M, Moscone A, Cunningham JW, Jering KS, Patel PN, Sinnenberg LE, Bernier TD, Buckley LF, Cook B, Dempsey J, Kelly J, Knowles DM, Lupi K, Malloy R, Matta LS, Rhoten MN, Sharma K, Snyder CA, Ting C, McElrath EE, Amato MG, Alobaidly M, Ulbricht CE, Choudhry NK, Adler DS, Vaduganathan M.

Eur J Heart Fail. 2021 Mar

Patient factors associated with new prescribing of potentially inappropriate medications in multimorbid US older adults using multiple medications

Jungo KT, Streit S, and Lauffenburger JC

BMC Geriatrics 2021 Mar

Rationale and design of the Novel Uses of adaptive Designs to Guide provider Engagement in Electronic Health Records (NUDGE-EHR) pragmatic adaptive randomized trial: a trial protocol

Lauffenburger JC, Isaac T, Trippa L, Keller P, Robertson T, Glynn RJ, Sequist TD, Kim DH, Fontanet CP, Castonguay EWB, Haff N, Barlev Ra, Mahesri M, Gopalakrishnan C, and Choudhry NK.

Implementation Science 2021 Jan

Use of Data-Driven Methods to Predict Long-term Patterns of Health Care Spending for Medicare Patients.

Lauffenburger JC, Mahesri M, Choudhry NK.

JAMA Netw Open. 2020 Oct

2020

Not there yet: using data-driven methods to predict who becomes costly among low-cost patients with type 2 diabetes.

Lauffenburger JC, Mahesri M, Choudhry NK.

BMC Endocr Disord. 2020 Aug

Comparison of a new three-item self-reported measure of adherence to medication with pharmacy claims data in patients with cardiometabolic disease.

Lauffenburger JC, Fontanet CP, Isaac T, Gopalakrishnan C, Sequist TD, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Choudhry NK.

Am Heart J 2020 Jun

Impact of a Copayment Reduction Intervention on Medication Persistence and Cardiovascular Events in Hospitals With and Without Prior Medication Financial Assistance Programs.

Doll JA, Kaltenbach LA, Anstrom KJ, Cannon CP, Henry TD, Fonarow GC, Choudhry NK, Fonseca E, Bhalla N, Eudicone JM, Peterson ED, Wang TY.

J Am Heart Assoc. 2020 Apr

Agreement and Accuracy of Medication Persistence Identified by Patient Self-report vs Pharmacy Fill: A Secondary Analysis of the Cluster Randomized ARTEMIS Trial.

Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY.

JAMA Cardiol. 2020 Mar

The accuracy of self-reported blood pressure in the Medication adherence Improvement Support App For Engagement - Blood Pressure (MedISAFE-BP) Trial: Implications for Pragmatic Trials.

Haff N, Lauffenburger JC, Morawski K, Ghazinouri R, Noor N, Kumar S, Juusola J, Choudhry NK.

Am Heart J. 2020 Feb

Prevalence and Impact of Having Multiple Barriers to Medication Adherence in Non-adherent Patients with Poorly-controlled Cardiometabolic Disease.

Lauffenburger JC, Isaac T, Bhattacharya R, Sequist TD, Gopalakrishnan C, Choudhry NK.

Am. J. Cardiol. 2020 Feb

Association of Potentially Modifiable Diabetes Care Factors With Glycemic Control in Patients With Insulin-Treated Type 2 Diabetes.

Lauffenburger JC, Lewey J, Jan S, Lee J, Ghazinouri R, Choudhry NK.

JAMA Netw Open. 2020 Jan

Association of a P2Y12 Inhibitor Copayment Reduction Intervention With Persistence and Adherence With Other Secondary Prevention Medications: A Post Hoc Analysis of the ARTEMIS Cluster-Randomized Clinical Trial.

Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY.

JAMA Cardiol. 2019 Nov

2019

Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.

Metes ID, Xue L, Chang C-CH, Huskamp HA, Gellad WF, Lo-Ciganic W-H, Choudhry NK, Richards-Shubik S, Guclu H, Donohue JM.

BMC Health Serv. Res 2019 Oct

Effect of Automated Immunization Registry-Based Telephonic Interventions on Adult Vaccination Rates in Community Pharmacies: A Randomized Controlled Trial.

Stolpe S, Choudhry NK.

Journal of Managed Care & Specialty Pharmacy 2019 Sep

A concept‐wide association study to identify potential risk factors for nonadherence among prevalent users of antihypertensives.

Singh K, Choudhry NK, Krumme AA, McKay C, McElwee NE, Kimura J, Franklin JM.

Pharmacoepidemiol Drug Saf. 2019 July

A bronchial-airway gene-expression classifier to improve the diagnosis of lung cancer: clinical outcomes and cost-effectiveness analysis.

D’Andrea E, Choudhry NK, Raby B, Weinhouse G, Najafzadeh M.

Int J Cancer. 2019 April

Impact of a novel pharmacist-delivered behavioral intervention for patients with poorly-controlled diabetes: The ENhancing outcomes through Goal Assessment and Generating Engagement in Diabetes Mellitus (ENGAGE-DM) pragmatic randomized trial.

Lauffenburger JC, Ghazinouri R, Jan S, Makanji S, Ferro CA, Lewey J, Wittbrodt E, Lee J, Haff N, Fontanet CP, Choudhry NK.

PLOS ONE. 2019 April 2

General Population vs. Patient Preferences in Anticoagulant Therapy: A Discrete Choice Experiment.

Najafzadeh M, Schneeweiss S, Choudhry NK, Avorn J, Gagne JJ.

Patient. 2019 April

Effect of Targeted Insulin Adherence Interventions for Glycemic Control With Predictive Analytics Among Patients With Type 2 Diabetes: The TARGIT-Diabetes Randomized Clinical Trial.

Lauffenburger JC, Lewey J, Jan S, Makanji S, Ferro CA, Krumme AA, Lee J, Ghazinouri R, Haff N, Choudhry NK.

JAMA Network Open 2019 March 15

Effect of medication co-payment vouchers on P2Y12 inhibitor use and major adverse cardiovascular events among patients with myocardial infarction: The ARTEMIS randomized clinical trial.

Wang TY, Kaltenbach LA, Cannon CP, Fonarow GC, Choudhry NK, et al.

JAMA 2019 January

Utilization Patterns of Oral Disease-Modifying Drugs in Commercially Insured Patients with Multiple Sclerosis.

Desai RJ, Mahesri M, Gagne JJ, Hurley E, Tong A, Chitnis T, Minden S, Spettell CM, Matlin OS, Shrank WH, Choudhry NK.

Journal of Managed Care and Specialty Pharmacy 2019 January

Quantifying Social Reinforcement Among Family Members on Adherence to Medications for Chronic Conditions: a US-Based Retrospective Cohort Study.

Lauffenburger JC, Khan NF, Brill G, Choudhry NK.

Journal of General Internal Medicine 2018 November 07

2018

Impact of High Deductible Health Plans on Cardiovascular Medication Adherence and Health Disparities.

Lewey J, Gagne JJ, Franklin J, Lauffenburger JC, Brill G, Choudhry NK.

Circulation: Quality and Outcomes 2018 November

Time to Filling of New Prescriptions for Chronic Disease Medications Among a Cohort of Elderly Patients in the USA.

Franklin JM, Mahesri M, Krumme AA, Barberio J, Fischer MA, Brill G, McKay C, Black H, Choudhry NK.

Journal of General Internal Medicine 2018 November

Using Previous Medication Adherence to Predict Future Adherence.

Kumamaru H, Lee MP, Choudhry NK, Dong Y-H, Krumme AA, Khan N, Brill G, Kohsaka S, Miyata H, Schneeweiss S, Gagne JJ.

Journal of Managed Care & Specialty Pharmacy 2018 October

The Promise and Pitfalls of Pragmatic Clinical Trials for Improving Health Care Quality.

Haff N, Choudhry NK.

JAMA Network Open 2018 October 26

Impact of a metoprolol ER shortage on post-myocardial infarction beta-blocker utilization, adherence, and re-hospitalization.

Bykov K, Gagne JJ, Wang B, Choudhry NK.

Circulation: Cardiovascular Quality and Outcomes 2018 October

Letters designed with behavioural science increase influenza vaccination in Medicare beneficiaries.

Yokum D, Lauffenburger J, Ghazinouri R, Choudhry NK.

Nature Human Behaviour 2018 October 01

Effect of a Remotely Delivered Tailored Multicomponent Approach to Enhance Medication Taking for Patients With Hyperlipidemia, Hypertension, and Diabetes: The STIC2IT Cluster Randomized Clinical Trial.

Choudhry NK, Isaac T, Lauffenburger JC, Gopalakrishnan C, Lee M, Vachon A, Iliadis TL, Hollands W, Elman S, Kraft JM, Naseem S, Doheny S, Lee J, Barberio J, Patel L, Khan NF, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD.

JAMA Internal Medicine. 2018 September

A Call for a Systems-Thinking Approach to Medication Adherence: Stop Blaming the Patient.

Lauffenburger JC, Choudhry NK.

JAMA Intern Med. 2018 July 01

Defining Exposure in Observational Studies Comparing Outcomes of Treatment Discontinuation.

Krumme AA, Glynn RJ, Schneeweiss S, Choudhry NK, Tong AY, Gagne JJ.

Circulation: Cardiovasc Qual Outcomes. 2018 July 10

Association of a smartphone application with medication adherence and blood pressure control - The MedISAFE-BP randomized clinical trial.

Morawski K, Ghazinouri R, Krumme A, Lauffenburger JC, Lu Z, Durfee E, Oley L, Lee J, Mohta N, Haff N, Juusola JL, Choudhry NK.

JAMA Intern Med. 2018 June

Predicting Adherence to Chronic Disease Medications in Patients with Long-term Initial Medication Fills Using Indicators of Clinical Events and Health Behaviors.

Lauffenburger JC, Franklin JM Krumme, AA, Shrank WH, Matlin OS, Spettell CM, Brill G, Choudhry NK.

J Manag Care Spec Pharm. 2018 May

The relative benefits of claims and electronic health record data for predicting medication adherence trajectory.

Franklin JM, Gopalakrishnan C, Krumme AA, Singh K, Rogers JR, Kimura J, McKay C, McElwee NE, Choudhry NK.

Am Heart J. 2018 March

Simulation for predicting effectiveness and safety of new cardiovascular drugs in routine care populations.

Najafzadeh M, Schneeweiss S, Choudhry NK, Wang SV, Gagne JJ.

Clin Pharmacol Ther. 2018 February 09

Medication synchronization programs improve adherence to cardiovascular medications and health care use.

Krumme AA, Glynn RJ, Schneeweiss S, Gagne JJ, Dougherty JS, Brill G, Choudhry NK.

Health Aff. 2018 January

Study protocol for the dabigatran, apixaban, rivaroxaban, edoxaban, warfarin comparative effectiveness research study.

Krumme AA, Pawar A, Schneeweiss S, Glynn RJ, Choudhry NK, Kulldorff M, Ortiz AS, Avorn J, Gagne JJ.

J Comp Eff Res. 2017 December 21

Older

Exploring attributes of high-value primary care.

Simon M, Choudhry NK, Frankfort J, Margolius D, Murphy J, Paita L, Wang T, Milstein A.

Ann Fam Med. 2017 November

Patterns of opioid initiation at first visits for pain in United States primary care settings.

Mundkur ML, Rough K, Huybrechts KF, Levin R, Gagne JJ, Desai RJ, Patorno E, Choudhry NK, Bateman BT.

Pharmacoepidemiol Drug Saf. 2017 October 02

Targeted Adherence intervention to Reach Glycemic control with Insulin Therapy for patients with Diabetes (TARGIT-Diabetes): rationale and design of a pragmatic randomised clinical trial.

Lewey J, Wei W, Lauffenburger JC, Makanji S, Chant A, DiGeronimo J, Nanchanatt G, Jan S, Choudhry NK.

BMJ Open. 2017 October 30

The impact of a retail prescription synchronization program on medication adherence.

Girdish C, Shrank W, Freytag S, Chen D, Gebhard D, Bunton A, Choudhry N, Polinski J.

J Am Pharm Assoc. 2017 September-October

Publications

Randomised controlled trial targeting habit formation to improve medication adherence to daily oral medications in patients with gout Fontanet CP, Choudhry NK, Wood W, Robertson T, Haff N, Oran R, Sears ES, Kim E, Hanken K, Barlev RA, Lauffenburger JC, Feldman CH BMJ Open 2021 Nov 24

Exploring patient experiences coping with using multiple medications: a qualitative interview study Lauffenburger JC, Haff N, McDonnell ME, Solomon DH, Antman EM, Glynn RJ, Choudhry NK BMJ Open 2021 Nov 22

Prevalence, predictors, and outcomes of both true- and pseudo-resistant hypertension in the action to control cardiovascular risk in diabetes trial: a cohort study Chiu N, Lauffenburger LC, Franklin JM, Choudhry NK Hypertens Res 2021 Nov

Comparison of measures of medication adherence from pharmacy dispensing and insurer claims data Fontanet CP, Choudhry NK, Isaac T, Sequist TD, Gopalakrishnan C, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Lauffenburger JC Health Serv Res 2021 Aug 13

Helping Patients Manage Their Own Blood Pressures: A Strategy to Address Hypertesnion Control in the United States Haff N, Choudhry NK Circ Cardiovasc Qual Outcomes​ 2021 Aug

Association Between Cost-Saving Prescription Policy Changes and Adherence to Chronic Disease Medications: an Observational Study Haff N, Sequist TD, Gibson TB, Benevent R, Sears SE, Chaguturu S, Lauffenburger JC J Gen Intern Med 2021 Jul 30

Impact of implementing electronic prior authorization on medication filling in an electronic health record system in a large healthcare system Lauffenburger LC, Stults CD, Mudiganti S, Yan X, Dean-Gilley LM, He M, Tong A, Fischer MA J Am Med Inform Assoc​ 2021 Jul 19