Publications

Overcoming decisional gaps in high-risk prescribing by junior physicians using simulation-based training: Protocol for a randomized controlled trial

Lauffenburger JC, DiFrancesco MF, Barlev RA, Robertson T, Kim E, Coll MD, Haff N, Fontanet CP, Hanken K, Oran R, Avorn J, Choudhry NK

 

JMIR Res Protoc. 2022 Apr

A novel modality for real-time measurement of provider happiness

Carlile N, Tantillo S, Brown M, Bates DW, Choudhry NK

 

JAMIA Open. 2022 Feb 24

Finishing Touches: Enhancing Scientific Communication Through Circulation: Cardiovascular Quality and Outcomes' Technical Review

Lauffenburger JC, Ho MP, Nallamothu BK
 

Circ Cardiovasc Qual Outcomes. 2021 Dec 21

Three Sides to the Story: Adherence Trajectories During the First Year of Sodium-Glucose Cotransporter 2 Inhibitor Therapy Among Medicare Beneficiaries

Hawley CE, Lauffenburger JC, Paik JM, Wexler DJ, Kim SC, Patorno E

 

Diabetes Care. 2022 Jan 17

Use of Data-Driven Methods to Predict Long-term Patterns of Health Care Spending for Medicare Patients.

Lauffenburger JC, Mahesri M, Choudhry NK.

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JAMA Netw Open. 2020 Oct

Not there yet: using data-driven methods to predict who becomes costly among low-cost patients with type 2 diabetes. 

Lauffenburger JC, Mahesri M, Choudhry NK.

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BMC Endocr Disord. 2020 Aug 

Comparison of a new three-item self-reported measure of adherence to medication with pharmacy claims data in patients with cardiometabolic disease. 

Lauffenburger JC, Fontanet CP, Isaac T, Gopalakrishnan C, Sequist TD, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Choudhry NK. 

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Am Heart J 2020 Jun

Impact of a Copayment Reduction Intervention on Medication Persistence and Cardiovascular Events in Hospitals With and Without Prior Medication Financial Assistance Programs.

Doll JA, Kaltenbach LA, Anstrom KJ, Cannon CP, Henry TD, Fonarow GC, Choudhry NK, Fonseca E, Bhalla N, Eudicone JM, Peterson ED, Wang TY.

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J Am Heart Assoc. 2020 Apr

Agreement and Accuracy of Medication Persistence Identified by Patient Self-report vs Pharmacy Fill: A Secondary Analysis of the Cluster Randomized ARTEMIS Trial.

Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY. 

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JAMA Cardiol. 2020 Mar

The accuracy of self-reported blood pressure in the Medication adherence Improvement Support App For Engagement - Blood Pressure (MedISAFE-BP) Trial: Implications for Pragmatic Trials. 

Haff N, Lauffenburger JC, Morawski K, Ghazinouri R, Noor N, Kumar S, Juusola J, Choudhry NK.

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Am Heart J. 2020 Feb

Prevalence and Impact of Having Multiple Barriers to Medication Adherence in Non-adherent Patients with Poorly-controlled Cardiometabolic Disease.

Lauffenburger JC, Isaac T, Bhattacharya R, Sequist TD, Gopalakrishnan C, Choudhry NK.

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Am. J. Cardiol. 2020 Feb

Association of Potentially Modifiable Diabetes Care Factors With Glycemic Control in Patients With Insulin-Treated Type 2 Diabetes.

Lauffenburger JC, Lewey J, Jan S, Lee J, Ghazinouri R, Choudhry NK.

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JAMA Netw Open. 2020 Jan

Association of a P2Y12 Inhibitor Copayment Reduction Intervention With Persistence and Adherence With Other Secondary Prevention Medications: A Post Hoc Analysis of the ARTEMIS Cluster-Randomized Clinical Trial.

Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY. 

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JAMA Cardiol. 2019 Nov 

Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.

Metes ID, Xue L, Chang C-CH, Huskamp HA, Gellad WF, Lo-Ciganic W-H, Choudhry NK, Richards-Shubik S, Guclu H, Donohue JM.

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BMC Health Serv. Res 2019 Oct

Effect of Automated Immunization Registry-Based Telephonic Interventions on Adult Vaccination Rates in Community Pharmacies: A Randomized Controlled Trial.

Stolpe S, Choudhry NK.

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Journal of Managed Care & Specialty Pharmacy 2019 Sep

A concept‐wide association study to identify potential risk factors for nonadherence among prevalent users of antihypertensives.

Singh K, Choudhry NK, Krumme AA, McKay C, McElwee NE, Kimura J, Franklin JM. 

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Pharmacoepidemiol Drug Saf. 2019 July

A bronchial-airway gene-expression classifier to improve the diagnosis of lung cancer: clinical outcomes and cost-effectiveness analysis. 

D’Andrea E, Choudhry NK, Raby B, Weinhouse G, Najafzadeh M. 

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Int J Cancer. 2019 April

Impact of a novel pharmacist-delivered behavioral intervention for patients with poorly-controlled diabetes: The ENhancing outcomes through Goal Assessment and Generating Engagement in Diabetes Mellitus (ENGAGE-DM) pragmatic randomized trial.

Lauffenburger JC, Ghazinouri R, Jan S, Makanji S, Ferro CA, Lewey J, Wittbrodt E, Lee J, Haff N, Fontanet CP, Choudhry NK.

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PLOS ONE. 2019 April 2

General Population vs. Patient Preferences in Anticoagulant Therapy: A Discrete Choice Experiment.

Najafzadeh M, Schneeweiss S, Choudhry NK, Avorn J, Gagne JJ.

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Patient. 2019 April

Effect of Targeted Insulin Adherence Interventions for Glycemic Control With Predictive Analytics Among Patients With Type 2 Diabetes: The TARGIT-Diabetes Randomized Clinical Trial. 

Lauffenburger JC, Lewey J, Jan S, Makanji S, Ferro CA, Krumme AA, Lee J, Ghazinouri R, Haff N, Choudhry NK. 

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JAMA Network Open 2019 March 15

Effect of medication co-payment vouchers on P2Y12 inhibitor use and major adverse cardiovascular events among patients with myocardial infarction: The ARTEMIS randomized clinical trial. 

Wang TY, Kaltenbach LA, Cannon CP, Fonarow GC, Choudhry NK, et al.

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JAMA 2019 January

Utilization Patterns of Oral Disease-Modifying Drugs in Commercially Insured Patients with Multiple Sclerosis.

Desai RJ, Mahesri M, Gagne JJ, Hurley E, Tong A, Chitnis T, Minden S, Spettell CM, Matlin OS, Shrank WH, Choudhry NK.

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Journal of Managed Care and Specialty Pharmacy 2019 January 

Quantifying Social Reinforcement Among Family Members on Adherence to Medications for Chronic Conditions: a US-Based Retrospective Cohort Study.

Lauffenburger JC, Khan NF, Brill G, Choudhry NK. 

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Journal of General Internal Medicine 2018 November 07

Impact of High Deductible Health Plans on Cardiovascular Medication Adherence and Health Disparities.

Lewey J, Gagne JJ, Franklin J, Lauffenburger JC, Brill G, Choudhry NK.

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Circulation: Quality and Outcomes 2018 November

Time to Filling of New Prescriptions for Chronic Disease Medications Among a Cohort of Elderly Patients in the USA.

Franklin JM, Mahesri M, Krumme AA, Barberio J, Fischer MA, Brill G, McKay C, Black H, Choudhry NK. 

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Journal of General Internal Medicine 2018 November

Using Previous Medication Adherence to Predict Future Adherence.

Kumamaru H, Lee MP, Choudhry NK, Dong Y-H, Krumme AA, Khan N, Brill G, Kohsaka S, Miyata H, Schneeweiss S, Gagne JJ. 

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Journal of Managed Care & Specialty Pharmacy 2018 October

The Promise and Pitfalls of Pragmatic Clinical Trials for Improving Health Care Quality.

Haff N, Choudhry NK.

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JAMA Network Open 2018 October 26

Impact of a metoprolol ER shortage on post-myocardial infarction beta-blocker utilization, adherence, and re-hospitalization.

Bykov K, Gagne JJ, Wang B, Choudhry NK. 

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Circulation: Cardiovascular Quality and Outcomes 2018 October

Letters designed with behavioural science increase influenza vaccination in Medicare beneficiaries.

Yokum D, Lauffenburger J, Ghazinouri R, Choudhry NK. 

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Nature Human Behaviour 2018 October 01

Effect of a Remotely Delivered Tailored Multicomponent Approach to Enhance Medication Taking for Patients With Hyperlipidemia, Hypertension, and Diabetes: The STIC2IT Cluster Randomized Clinical Trial.

Choudhry NK, Isaac T, Lauffenburger JC, Gopalakrishnan C, Lee M, Vachon A, Iliadis TL, Hollands W, Elman S, Kraft JM, Naseem S, Doheny S, Lee J, Barberio J, Patel L, Khan NF, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD.

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JAMA Internal Medicine. 2018 September

A Call for a Systems-Thinking Approach to Medication Adherence: Stop Blaming the Patient.

Lauffenburger JC, Choudhry NK.

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JAMA Intern Med. 2018 July 01

Defining Exposure in Observational Studies Comparing Outcomes of Treatment Discontinuation.

Krumme AA, Glynn RJ, Schneeweiss S, Choudhry NK, Tong AY, Gagne JJ.

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Circulation: Cardiovasc Qual Outcomes. 2018 July 10

Association of a smartphone application with medication adherence and blood pressure control - The MedISAFE-BP randomized clinical trial.

Morawski K, Ghazinouri R, Krumme A, Lauffenburger JC, Lu Z, Durfee E, Oley L, Lee J, Mohta N, Haff N, Juusola JL, Choudhry NK.

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JAMA Intern Med. 2018 June

Predicting Adherence to Chronic Disease Medications in Patients with Long-term Initial Medication Fills Using Indicators of Clinical Events and Health Behaviors.

Lauffenburger JC, Franklin JM Krumme, AA, Shrank WH, Matlin OS, Spettell CM, Brill G, Choudhry NK.

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J Manag Care Spec Pharm. 2018 May

The relative benefits of claims and electronic health record data for predicting medication adherence trajectory.

Franklin JM, Gopalakrishnan C, Krumme AA, Singh K, Rogers JR, Kimura J, McKay C, McElwee NE, Choudhry NK.

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Am Heart J. 2018 March

Simulation for predicting effectiveness and safety of new cardiovascular drugs in routine care populations.

Najafzadeh M, Schneeweiss S, Choudhry NK, Wang SV, Gagne JJ.

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Clin Pharmacol Ther. 2018 February 09

Medication synchronization programs improve adherence to cardiovascular medications and health care use.

Krumme AA, Glynn RJ, Schneeweiss S, Gagne JJ, Dougherty JS, Brill G, Choudhry NK.

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Health Aff. 2018 January

Study protocol for the dabigatran, apixaban, rivaroxaban, edoxaban, warfarin comparative effectiveness research study.

Krumme AA, Pawar A, Schneeweiss S, Glynn RJ, Choudhry NK, Kulldorff M, Ortiz AS, Avorn J, Gagne JJ.

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J Comp Eff Res. 2017 December 21

Exploring attributes of high-value primary care.

Simon M, Choudhry NK, Frankfort J, Margolius D, Murphy J, Paita L, Wang T, Milstein A.

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Ann Fam Med. 2017 November

Patterns of opioid initiation at first visits for pain in United States primary care settings.

Mundkur ML, Rough K, Huybrechts KF, Levin R, Gagne JJ, Desai RJ, Patorno E, Choudhry NK, Bateman BT.

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Pharmacoepidemiol Drug Saf. 2017 October 02

Targeted Adherence intervention to Reach Glycemic control with Insulin Therapy for patients with Diabetes (TARGIT-Diabetes): rationale and design of a pragmatic randomised clinical trial.

Lewey J, Wei W, Lauffenburger JC, Makanji S, Chant A, DiGeronimo J, Nanchanatt G, Jan S, Choudhry NK.

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BMJ Open. 2017 October 30

The impact of a retail prescription synchronization program on medication adherence.

Girdish C, Shrank W, Freytag S, Chen D, Gebhard D, Bunton A, Choudhry N, Polinski J.

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J Am Pharm Assoc. 2017 September-October

The impact of text messaging on medication adherence and exercise among postmyocardial infarction patients: randomized controlled pilot trial.

Pandey A, Krumme A, Patel T, Choudhry NK.

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JMIR Mhealth Uhealth. 2017 August

Rationale and design of the ENhancing outcomes through Goal Assessment and Generating Engagement in Diabetes Mellitus (ENGAGE-DM) pragmatic trial.

Lauffenburger JC, Lewey J, Jan S, Nanchanatt G, Makanji S, Ferro CA, Sheehan J, Wittbrodt E, Morawski K, Lee J, Ghazinouri R, Choudhry NK.

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Contemp Clin Trials. 2017 August

Cost-effectiveness of palbociclib in hormone receptor-positive advanced breast cancer.

Mamiya H, Tahara RK, Tolaney SM, Choudhry NK, Najafzadeh M.

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Ann Oncol. 2017 August 01

Hypertension management in Brazil: usual practice in primary care - a meta-analysis.

Picon RV, Dias-da-Costa JS, Fuchs FD, Olinto MTA, Choudhry NK, Fuchs SC.

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Int J Hypertens. 2017 July 02

A shared decision-making intervention to guide opioid prescribing after cesarean delivery.

Prabhu M, McQuaid-Hanson E, Hopp S, Burns SM, Leffert LR, Landau R, Lauffenburger JC, Choudhry NK, Kaimal A, Bateman BT.

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Obstet Gynecol. 2017 July

Effect of reminder devices on medication adherence: the REMIND randomized clinical trial.

Choudhry NK, Krumme AA, Ercole PM, Girdish C, Tong A, Khan N, Brennan TA, Matlin OS, Shrank WH, Franklin JM.

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JAMA Intern Med. 2017 May

Patterns and predictors of persistent opioid use following hip or knee arthroplasty.

Kim SC, Choudhry N, Franklin JM, Bykov K, Eikermann M, Lii J, Fischer MA, Bateman BT.

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Osteoarthritis Cartilage. 2017 April 19

Rationale and design of the Medication adherence Improvement Support App For Engagement - Blood Pressure (MedISAFE-BP) trial.

Morawski K, Ghazinouri R, Krumme A, McDonough J, Durfee E, Oley L, Mohta N, Juusola J, Choudhry NK.

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Am Heart J. 2017 April

Predicting 1-year statin adherence among prevalent users: a retrospective cohort study.

Krumme AA, Franklin JM, Isaman DL, Matlin OS, Tong AY, Spettell CM, Brennan TA, Shrank WH, Choudhry NK.

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J Manag Care Spec Pharm. 2017 April

Clinical outcomes of concomitant use of warfarin and selective serotonin reuptake inhibitors: a multidatabase observational cohort study.

Dong YH, Bykov K, Choudhry NK, Donneyong MM, Huybrechts KF, Levin R, Schneeweiss S, Gagne JJ

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J Clin Psychopharmacol. 2017 April

Impact of hospitalization on medication adherence estimation in claims data.

Dong Y-H, Choudhry NK, Krumme A, Lee MP, Wu LC, Lai MS, Gagne JJ.

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J Clin Pharm Ther. 2017 March 29

Association between patient-centered medical homes and adherence to chronic disease medications: a cohort study.

Lauffenburger JC, Shrank WH, Bitton A, Franklin JM, Glynn RJ, Krumme AA, Matlin OS, Pezalla EJ, Spetell CM, Brill G, Choudhry NK.

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Ann Intern Med. 2017 January 17

Longitudinal patterns of spending enhance the ability to predict costly patients: a novel approach to identify patients for cost containment.

Lauffenburger JC, Franklin JM, Krumme AA, Shrank WH, Brennan TA, Matlin OS, Spettell CM, Brill G, Choudhry NK.

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Med Care. 2017 January

Impact of an interaction between clopidogrel and selective serotonin reuptake inhibitors.

Bykov K, Schneeweiss S, Donneyong MM, Dong YH, Choudhry NK, Gagne JJ.

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Am J Cardiol. 2016 November 16

Can purchasing information be used to predict adherence to cardiovascular medications? An analysis of linked retail pharmacy and insurance claims data.

Krumme AA, Sanfelix-Gimeno G, Franklin JM, Isaman DL, Mahesri M, Matlin OS, Shrank WH, Brennan TA, Brill G, Choudhry NK.

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BMJ Open. 2016 November 09

Switching generic antiepileptic drug manufacturer not linked to seizures: A case-crossover study.

Kesselheim AS, Bykov K, Gagne JJ, Wang SV, Choudhry NK.

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Neurology. 2016 October 25

Strength of evidence for labeled dosing recommendations in renal impairment.

Gagne JJ, Khan NF, Raj TS, Patel LR, Choudhry NK.

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Clin Trials. 2016 October 24

Economic value of pharmacist-led medication reconciliation for reducing medication errors after hospital discharge.

Najafzadeh M, Schnipper JL, Shrank WH, Kymes S, Brennan TA, Choudhry NK.

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Am J Manag Care. 2016 October 14

Rationale and design of the Study of a Tele-pharmacy Intervention for Chronic diseases to Improve Treatment adherence (STIC2IT): A cluster-randomized pragmatic trial.

Choudhry NK, Isaac T, Lauffenburger JC, Gopalakrishnan C, Khan NF, Lee M, Vachon A, Iliadis TL, Hollands W, Doheny S, Elman S, Kraft JM, Naseem S, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD.

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Am Heart J. 2016 October

Persistent opioid use following cesarean delivery: patterns and predictors among opioid-naive women.

Bateman BT, Franklin JM, Bykov K, Avorn J, Shrank WH, Brennan TA, Landon JE, Rathmell JP, Huybrechts KF, Fischer MA, Choudhry NK.

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Am J Obstet Gynecol. 2016 September

Potentially disruptive life events: what are the immediate impacts on chronic disease management? A case-crossover analysis.

Lauffenburger JC, Gagne JJ, Song Z, Brill G, Choudhry NK.

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BMJ Open. 2016 August 04

Impact of Massachusetts health reform on enrollment length and health care utilization in the unsubsidized individual market.

Garabedian LF, Ross-Degnan D, Soumerai SB, Choudhry NK, Brown JS.

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Health Serv Res. 2016 July 25

Rationale and design of the Affordability and Real-world Antiplatelet Treatment Effectiveness after Myocardial Infarction Study (ARTEMIS): A multicenter, cluster-randomized trial of P2Y12 receptor inhibitor copayment reduction after myocardial infarction.

Doll JA, Wang TY, Choudhry NK, Cannon CP, Cohen DJ, Fonarow GC, Henry TD, Bhandary DD7, Khan N, Davidson-Ray LD, Anstrom K, Peterson ED.

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Am Heart J. 2016 July

Who were the early adopters of dabigatran?: an application of group-based trajectory models.

Lo-Ciganic WH, Gellad WF, Huskamp HA, Choudhry NK, Chang CC, Zhang R, Jones BL, Guclu H, Richards-Shubik S, Donohue JM.

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Med Care. 2016 July

Limiting the duration of opioid prescriptions balancing excessive prescribing and the effective treatment of pain.

Bateman BT, Choudhry NK.

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JAMA Intern Med. 2016 May

Prevalence, effectiveness, and characteristics of pharmacy-based medication synchronization programs.

Krumme AA, Isaman DL, Stolpe SF, Dougherty S, Choudhry NK.

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Am J Manag Care. 2016 March

Brief Report: Intensification to triple therapy after treatment with nonbiologic disease-modifying antirheumatic drugs for rheumatoid arthritis in the United States from 2009 to 2014.

Sparks JA, Krumme AA, Shrank WH, Matlin OS, Brill G, Pezalla EJ, Choudhry NK, Solomon DH.

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Arthritis Rheumatol. 2016 February 11

Medicaid prescription limits: policy trends and comparative impact on utilization.

Lieberman DA, Polinski JM, Choudhry NK, Avorn J, Fischer MA.

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BMC Health Serv Res. 2016 January 15

Text messaging and patient engagement in an increasingly mobile world.

Lauffenburger JC, Choudhry NK.

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Circulation. 2016 January 14

Improving Adherence to Therapy and Clinical Outcomes While Containing Costs: Opportunities From the Greater Use of Generic Medications: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians.

Choudhry NK, Denberg TD, Qaseem A, Clinical Guidelines Committee of the American College of Physicians.

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Ann Intern Med. 2016 January 05

Prospective benefit-risk monitoring of new drugs for rapid assessment of net favorability in electronic health care data.

Gagne JJ, Bykov K, Najafzadeh M, Choudhry NK, Martin DP, Kahler KH, Rogers JR, Schneeweiss S.

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Value Health. 2015 December

Comparison of benefit-risk assessment methods for prospective monitoring of newly marketed drugs: a simulation study.

Gagne JJ, Najafzadeh M, Choudhry NK, Bykov K, Kahler KH, Martin D, Rogers JR, Schneeweiss S.

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Value Health. 2015 December

Evaluating Cardiovascular Health Disparities Using Estimated Race/Ethnicity: A Validation Study.

Bykov K, Franklin JM, Toscano M, Rawlins W, Spettell CM, McMahill-Walraven CN, Shrank WH, Choudhry NK.

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Med Care. 2015 December

Comparative effectiveness of generic versus brand-name antiepileptic medications.

Gagne JJ, Kesselheim AS, Choudhry NK, Polinski JM, Hutchins D, Matlin OS, Brennan TA, Avorn J, Shrank WH.

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Epilepsy Behav. 2015 November

Community pharmacy automatic refill program improves adherence to maintenance therapy and reduces wasted medication.

Matlin OS, Kymes SM, Averbukh A, Choudhry NK, Brennan TA, Bunton A, Ducharme TA, Simmons PD, Shrank WH.

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Am J Manag Care. 2015 November 13

Medication adherence and healthcare disparities: impact of statin co-payment reduction.

Lewey J, Shrank WH, Avorn J, Liu J, Choudhry NK.

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Am J Manag Care. 2015 October 09

Predicting adherence trajectory using initial patterns of medication filling.

Franklin JM, Krumme AA, Shrank WH, Matlin OS, Brennan TA, Choudhry NK.

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Am J Manag Care. 2015 September 17

Rationale and design of the Randomized Evaluation to Measure Improvements in Non-adherence from Low-Cost Devices (REMIND) trial.

Choudhry NK, Krumme AA, Ercole PM, Girdish C, Isaman DL, Matlin OS, Brennan TA, Shrank WH, Franklin JM.

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Contemp Clin Trials. 2015 July

Selective serotonin reuptake inhibitor use and perioperative bleeding and mortality in patients undergoing coronary artery bypass grafting: a cohort study.

Gagne JJ, Polinski JM, Rassen JA, Fischer MA, Seeger JD, Franklin JM, Liu J, Schneeweiss S, Choudhry NK.

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Drug Saf. 2015 July 19

Patient Use of Email, Facebook, and Physician Websites to Communicate with Physicians: A National Online Survey of Retail Pharmacy Users.

Lee JL, Choudhry NK, Wu AW, Matlin OS, Brennan TA, Shrank WH.

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J Gen Intern Med. 2015 June 24

Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study.

Kim SC, Schneeweiss S, Choudhry N, Liu J, Glynn RJ, Solomon DH.

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Am J Med. 2015 June

Long-term cost-effectiveness of providing full coverage for preventive medications after myocardial infarction.

Ito K, Avorn J, Shrank WH, Toscano M, Spettel C, Brennan T, Choudhry NK.

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Circ Cardiovasc Qual Outcomes. 2015 May