Forgetfulness is a major contributor to nonadherence to chronic disease medications and could be addressed with medication reminder devices. To address this barrier, the REMIND trial sought to compare the effect of 3 low-cost reminder devices on medication adherence. The trial is a 4-arm, block-randomized clinical trial involving 53, 480 enrollees of CVS Caremark across the United States. Patients were randomized to receive in the mail a pill bottle strip with toggles, digital timer cap, or standard pillbox. There was no statistically significant difference in the odds of optimal adherence between the control and any of the devices.