Forgetfulness is a major contributor to nonadherence to chronic disease medications and could be addressed with medication reminder devices. To address this barrier, the Randomized Evaluation to Measure Improvements in Nonadherence from Low-Cost Devices (REMIND) trial (n=53,480) was conducted in partnership with CVS Caremark and sought to compare the effect of 3 low-cost reminder devices on medication adherence. There was no statistically significant difference in the odds of optimal adherence between the control and any of the devices.