Low back and neck pain are among the leading causes of medical visits, lost productivity and disability. There is an urgent need to identify ways of helping patients with acute spine pain while guiding practitioners towards high-value care. The Spine Pain INtervention to Enhance Care quality And Reduce Expenditure (SPINE CARE) enrolled 2,971 patients from 33 centers nationally and tested the impact of a two new care models. The first was a risk-stratified, multidisciplinary intervention called the Identify, Coordinate, and Enhance [ICE] care model that combines physical therapy, health coach counseling, and consultation from a specialist in rehabilitation. The second was an individualized postural therapy approach, which combines physical therapy with building self-efficacy and self-management. Both interventions resulted in significant improvements in pain-related disability that were sustained at 12 months. The ICE intervention also reduced health spending.