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STIC2IT

Disagreement between pharmacy claims and direct interview to identify patients with non-adherence to chronic cardiometabolic medications

Haff N, Choudhry NK, Isaac T, Bhatkhande G, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD, Lauffenburger JC

Am Heart J

2023 February

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Comparison of measures of medication adherence from pharmacy dispensing and insurer claims data

Fontanet CP, Choudhry NK, Isaac T, Sequist TD, Gopalakrishnan C, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Lauffenburger JC

Health Serv Res

2022 June

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Comparison of a new three-item self-reported measure of adherence to medication with pharmacy claims data in patients with cardiometabolic disease. 

Lauffenburger JC, Fontanet CP, Isaac T, Gopalakrishnan C, Sequist TD, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Choudhry NK. 

Am Heart J

2020 June

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Prevalence and Impact of Having Multiple Barriers to Medication Adherence in Non-adherent Patients with Poorly-controlled Cardiometabolic Disease.

Lauffenburger JC, Isaac T, Bhattacharya R, Sequist TD, Gopalakrishnan C, Choudhry NK

Am J Cardiol

2020 February

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Effect of a Remotely Delivered Tailored Multicomponent Approach to Enhance Medication Taking for Patients With Hyperlipidemia, Hypertension, and Diabetes: The STIC2IT Cluster Randomized Clinical Trial.

Choudhry NK, Isaac T, Lauffenburger JC, Gopalakrishnan C, Lee M, Vachon A, Iliadis TL, Hollands W, Elman S, Kraft JM, Naseem S, Doheny S, Lee J, Barberio J, Patel L, Khan NF, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD.

JAMA Internal Medicine

2018 September

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Rationale and design of the Study of a Tele-pharmacy Intervention for Chronic diseases to Improve Treatment adherence (STIC2IT): A cluster-randomized pragmatic trial.

Choudhry NK, Isaac T, Lauffenburger JC, Gopalakrishnan C, Khan NF, Lee M, Vachon A, Iliadis TL, Hollands W, Doheny S, Elman S, Kraft JM, Naseem S, Gagne JJ, Jackevicius CA, Fischer MA, Solomon DH, Sequist TD.

Am Heart J

2016 October

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The efficacy of interventions to improve adherence may be increased by targeting interventions to patients that demonstrate both poor adherence and poor disease control, tailoring interventions to individual patient needs, and touching larger and more representative patient populations and care settings. The Study of a Tele-pharmacy Intervention for Chronic diseases to Improve Treatment adherence (STIC2IT) trial was conducted in partnership with Atrius and enrolled 4,078 patients to evaluate the impact of a novel tele-pharmacist intervention on adherence to maintenance medications. The intervention improved adherence, reduced the likelihood of emergency department visits and reduced cholesterol levels although did not influence other measures of resource utilization or disease control.

ClinicalTrials.gov: NCT02512276

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Co-Principal Investigators: Niteesh Choudhry, MD, PhD and Thomas Sequist, MD, MPH

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